Preclinical Development – Toxicologic Pathology, Davis CA,
Evaluation of preclinical development projects for Covance Laboratories and StageBio Laboratories. Twenty-one years of experience in the pharmaceutical industry, preclinical development, and safety studies. Toxicologic pathologist for non-GLP and GLP preclinical studies in support of FDA submissions. Expertise in histopathology, immunohistochemistry, drug antibody conjugates, monoclonal antibodies, biosimilars, tissue cross reactivity, digital pathology, and necropsy supervision. Histopathology peer review and report evaluation. Excelent nterpersonal skills for scientific interaction in study design and program development. Special interest in non-human primate pathology. Pathology rounds and consultation at the University of California-Davis School of Veterinary Medicine. 40 scientific publications.
Senior Veterinary Pathologist, Charles River Laboratories, Preclinical Sciences, Reno, NV,
Pathologist on preclinical toxicology studies and project teams involving data evaluation and IND and NDA preparation for FDA submission. Study design, method development, and peer review. Compliance with GLP and SOPs for study of biotherapeutic and small molecule drug development, drug antibody conjugates, monoclonal antibodies, biosimilars, digital pathology, immunopathology, and tissue cross-reactivity.
Senior Veterinary Pathologist, Roche Pharmaceuticals, Non-Clinical Drug Safety, Palo Alto, CA
Pathologist on toxicology projects and discovery planning teams in support of new drug development: study director, CRO peer review, histopathology, genetically engineered mice, and hepatic and cardiac model development. Interpreted data from pathology and toxicology studies and prepared reports for Investigator’s Brochures and FDA submissions. Generated pathology data in accordance with GLPs and internal SOPs for both biologics and small molecules. Global manager of pathology computer system. Provided recommendations on appropriate methodologies and study design to obtain optimal information.
PhD in Comparative Pathology, University of California, Davis,
Diplomate, American College of Veterinary Pathologists
DVM Kansas State University
Pathology Resident, The Animal Medical Center and the New York Zoological Society, NY
Research Fellow, Sloan-Kettering Institute for Cancer Research, NY
Intern in Medicine and Surgery, Henry Bergh Memorial Hospital of the ASPCA
PROFESSIONAL ASSOCIATIONS
Society of Toxicologic Pathologists
American College of Veterinary Pathologists
CL Davis Foundation
American Veterinary Medical Association
PRESENTATIONS
Malaria Recrudescence in a Toxicology Study with Macaca fascicuaris. CL Davis/West Coast Veterinary Pathology Conference, May 2016, University of California, Davis.
Simian Parvovirus Bone Marrow Infection in Cynomolgus Monkeys. CL Davis/West Coast Veterinary Pathology Conference, May 2013, University of California, Davis.
PUBLICATIONS
Meierhenry and J Eighmy, Simian Parvovirus Bone Marrow Infection in Cynomolgus Monkeys, in preparation, 2020.
Long, R. LoBosco, E. Meierhenry, et al., Comparative Assessment of Automated Analysis Using Computer-Assisted Pathology (CAPS™) HistoPATH™ Software, The Toxicologist, p.111, Society of Toxicology 2012.
Chiu, E. Meierhenry, and M. Garcia, Predictive Model of Growth and Male Sexual Maturity in the Cynomolgus Monkey (Macaca fascicularis), Proceedings of the American Association for Laboratory Animal Science (AALAS) Annual Meeting, 2009.
Fielden, E. Meierhenry, H. Uppal, and K. Kolaja, Preclinical Assessment and Biomarker Discovery of Drug-Induced Hepatic Steatosis, The Toxicologist, Vol. 108, March 2009.
Frantz, D. Misner, E. Meierhenry, et al., Safety Assessment for Compounds with Potential Cardiovascular Toxicity, Toxicol. Pathol. 37:129-130, 2008.
Frantz, D. Misner, E. Meierhenry, et al., A Cardiovascular Assessment Paradigm for the Early Identification of Proarrhythmic and Torsadagenic Compounds, The Toxicologist 102:1, 475, 2008.
Omana-Zapata, M. Shankaran, E. Meierhenry, and D. Bonhaus, Combined Paroxetine + Pindolol Treatment Enhances Cell Loss in Olfactory Bulbectomized Rats, Proceedings of the Society of Neuroscience Annual Meeting, 2002.
Gammon, J. Frank, E. Meierhenry, and K. Pfeifer, Triazine Herbicide Oncogenicity is Unlikely to be Due to Nitroso Formation, Proceedings of the International Union of Pure and Applied Chemistry Annual Meeting, 2002.
J. Graziano, J. W. Henck, E. F. Meierhenry, and A. W. Gough, Neurotoxicity of Misonidazole in Rats Following Intravenous Administration, Pharmacol. Res. 33:307-318, 1996.
J. Graziano, C. L. Courtney, E. F. Meierhenry, et al., Carcinogenicity of the Anticancer Topoisomerase Inhibitor Amsacrine in Wistar Rats, Fund. Appl. Toxicol. 32:53-65, 1996.
Kellner and E. Meierhenry, Experimental Neurotoxicity of the Thiocarbamate Herbicides Cycloate and EPTC, Proceedings of the Northern California Society of Toxicology Annual Meeting, 1994.
D. Dietz, M. R. Elwel, W. E. Davis, and E. F. Meierhenry, Subchronic Toxicity of Barium Chloride Dihydrate Administered to Rats and Mice in the Drinking Water, Fund. Appl. Toxicol. 19:527-537, 1992.
L. Courtney, K. L. Hawkins, E. F. Meierhenry, and M. Graziano, Immunohistochemical and Ultrastructural Characterization of Granular Cell Tumors of the Female Reproductive System in Two Aged Wistar Rats, Vet. Pathol. 29:86-89, 1992.
W. Henck, D. J. Trexler, E. Allen, E. F. Meierhenry, and M. Graziano, Neurotoxicity of the Radiosensitizer Misonidazole in Rats, The Toxicologist 11:8, 1991.
F. Meierhenry, Literature Review: The Effects of Inanition on Rat Bone Marrow, Toxicol. Pathol. 18:707-708, 1990.
R. Bucher, J. Huff, J. K. Haseman, S. L. Eustis, M. R. Elwell, W. E. Davis, and E. F. Meierhenry, Toxicology and Carcinogenicity Studies of Diuretics in F344 Rats and B6C3F1 Mice: Hydrochlorothiazide, J. Appl. Toxicol. 10:359-368, 1990.
R. Bucher, J. Huff, J. K. Haseman, S. L. Eustis, W. E. Davis, and E. F. Meierhenry, Toxicology and Carcinogenicity Studies of Diuretics in F344 Rats and B6C3F1 Mice: Furosemide, J. Appl. Toxicol. 10:369-378, 1990.
W. Henck, J. S. Schardein, E. F. Meierhenry, and J. A. Anderson, Reproductive Toxicity of the Anticonvulsant CI-946, The Toxicologist 10:222, 1990.
L. Steinmetz, C. K. Tyson, E. F. Meierhenry, and J. Mirsalis, Examination of Genotoxicity, Toxicity, and Morphologic Alterations in Hepatocytes Following In Vivo or In Vitro Exposure to Methapyrilene, Carcinogenesis 9:953-963, 1988.
L. Story, E. F. Meierhenry, C. A. Tyson, and H. Milman, Differences in Rat Liver Enzyme Altered Foci Produced by Chlorinated Alphatics and Phenobarbital, Toxicol. Indust. Health 2:351-362, 1987.
Steinmetz, C. Tyson, M. Ramsey, E. Meierhenry, J. Spalding, and J. Mirsalis, Examination of the Induction of Hepatic Unscheduled DNA Synthesis (UDS) and S-Phase Synthesis (SPS) Following In Vivo or In Vitro Exposure to Methapyrilene, The Toxicologist 7:100, 1987.
Bull, J. Brown, E. Meierhenry, et al., Enhancement of the Hepatotoxicity of Chloroform in B6C3F1 Mice by Corn Oil: Implications for Chloroform Carcinogenicity. Environ. Health Perspec. 69:49-58, 1986.
I. Dawson, P. D. Hobbs, R. Chan, R. Derdanski, C. T. Helmes, W. Chan, E. Meierhenry, and J. Shiff, Conformational Restriction of the Retinoid Skeleton, In Retinoids, Differentiation and Disease, Ciba Foundation Symposium 113, Ciba Foundation, London, 1985, pp. 6-28.
A. Jorgenson, E. F. Meierhenry, C. F. Rushbrook, et al., Carcinogenicity of Chloroform in Drinking Water to Male Osborne-Mendel Rats and Female B6C3F1 Mice, Fund. Appl. Toxicol. 5:760-769, 1985.
A. Tyson, D. L. Story, C. E. Green, and E. F. Meierhenry, Traditionally Used Indicators in Relation to Pathologic Lesions, In Laboratory Tests for Hepatic, Renal, Cardiovascular, and Pulmonary Function, C. A. Tyson and D. W. Sawhney (eds.), Noyes Publications, Park Ridge, NJ, 1985, pp. 23-90.
Ruebner, M. Gershwin, E. Meierhenry, L. Hsieh, and P. Dunn, Irreversibility of Liver Tumors in C3H Mice, J. Natl. Cancer Inst. 73:493, 1984.
Thomas, J. Mathewson, P. Suter, J. Reed, and E. Meierhenry, Hypertrophic Obstructive Cardiomyopathy in a Dog: Clinical, Hemodynamic, Angiographic, and Pathologic Studies, J. Am. Animal Hosp. Assoc. 20:253, 1984.
H. Ruebner, M. E. Gershwin, S. W. French, E. F. Meierhenry, et al., Mouse Hepatic Neoplasia: Differences Among Strains and Carcinogens, In Current Perspectives in Mouse Liver Neoplasia, J. A. Popp (ed.), Hemisphere Publishing Company, NY, 1984, pp. 144-158.
A. Howd, E. F. Meierhenry, and R. H. Suva, Miscellaneous Cancer Markers, In Markers of Chemically Induced Cancer, G. Freeman and H. Milman (eds.), Noyes Publications, Park Ridge, NJ, 1984, pp. 37-72.
A. Tyson, S. J. Gee, and E. F. Meierhenry, Hepatic and Renal Enzymes: Indicators of Preneoplastic or Early Neoplastic Lesions, In Markers of Chemically Induced Cancer, G. Freeman and H. Milman (eds.), Noyes Publications, Park Ridge, NJ, 1984, pp. 144-177.
F. Meierhenry, B. H. Ruebner, L. S. Hsieh, and S. W. French, Dieldrin-Induced Mallory Bodies in Hepatic Tumors of Mice of Different Strains, Hepatology 4:90, 1983.
H. Ruebner, M. E. Gershwin, E. F. Meierhenry, and L. P. Dunn, Enzyme Histochemical Characteristics of Spontaneous and Induced Hepatocellular Neoplasms in Mice, Carcinogenesis 3:899, 1982.
H. Ruebner and E. F. Meierhenry, Mallory Bodies in Hepatic Tumors Induced by Dieldrin, Fed. Proc. 40:744, 1981.
F. Meierhenry, B. H. Ruebner, and M. E. Gershwin, Mallory Body Formation in Mice Ingesting Dieldrin, Lab. Invest. 44:392, 1981.
F. Meierhenry and S.-K. Liu, Atrioventricular Bundle Degeneration Associated with Sudden Death in the Dog, J. Am. Vet. Med. Assoc. 172:1418, 1978.
W. Zontine, E. F. Meierhenry, and R. F. Hicks, Perforated Duodenal Ulcer Associated with Mastocytoma in a Dog, J. Am. Vet. Radiol. Assoc. 18:162, 1978.
L. Helphery and E. F. Meierhenry, Vulvar Leiomyosarcoma Metastatic to the Spinal Cord in a Dog, J. Am. Vet. Med. Assoc. 172:583, 1978.
F. Meierhenry and L. W. Clausen, Sarcoptic Mange in Collard Peccaries, J. Am. Vet. Med. Assoc. 171:983, 1977.
F. Burk, E. F. Meierhenry, and C. W. Schaubhet, Leiomyosarcoma of the Urinary Bladder in a Cat, J. Am. Vet. Med. Assoc. 167:749, 1975.
W. Hess and E. F. Meierhenry, Management of Canine and Feline Oral and Pharyngeal Tumors, Proceedings 42nd Annual Meeting, American Animal Hospital Association, Vol. II, p. 122, 1975.
F. Meierhenry, Metastatic Liposarcoma with Extensive Osteolysis in the Dog, J. Am Animal Hosp. Assoc. 10:478, 1974.