SIGNALMENT: (age, breed, sex, species, and scientific name)
Compound X= 1,3-dinitrobenzene
LABORATORY RESULTS: (clinical pathology, microbiology, etc…)
MORPHOLOGIC DIAGNOSIS AND ETIOLOGY:
Ethylene glycol monomethyl ether (Compound Y): Figure 4 shows a Stage I seminiferous tubule with degeneration of pachytene spermatocytes and presence a multinucleated giant cell (syncytia of round spermatids). Figure 5 shows a Stage V-VI seminiferous tubule with Step 18-19 spermatids adjacent to a single layer of type B spermatagonia and Sertoli cells. There is a complete absence of pachytene spermatocytes and round spermatids in this seminiferous tubule. The pachytene spermatocyte is considered the primary target cell for this glycol ether compound.
2. Chapin, RE, et al. 1985. The Recovery of the Testis over 8 Weeks after Short-Term Dosing with EGME: Histology, Cell-Specific Enzymes, and rete Testis Fluid Protein. Fund. Appl Tox. 5: 515-525.
Sprague-Dawley rat, male. PAS staining. 40X magnification. Control animal.
Sprague-Dawley rat exposed to Compound X, Day 5. PAS staining. 40X magnification.