SIGNALMENT: (age, breed, sex, species, and scientific name)
TREATMENT PROTOCOL: (including test compound)
LABORATORY RESULTS: (clinical pathology, microbiology, etc…)
Liver arsenic content was 353 ppm (reference level is 0.004-0.4 ppm) and rumen content arsenic level was 1200 ppm
Inorganic arsenic poisoning is no longer common due to the decreased use of herbicides and insecticides containing arsenic. However, many sources are still available and animals may be poisoned through ingestion or percutaneous absorption. Arsenic does not stay in the tissues very long. It is partially methylated in the liver and kidney and is rapidly excreted in urine, feces, bile, milk, saliva, and sweat.
Organic arsenicals, p-aminophenylarsonic acid (arsanilic acid) and 3-nitro-4-hydroxyphenylarsonic acid (3-Nitro), are commonly used as feed additives for swine, to promote growth and control enteric disease. Two syndromes related to accidental poisoning by these compounds have been described. Unlike inorganic arsenicals, lesions are mostly confined to the central nervous system.
2. Jones TC, et al., Veterinary Pathology, 6th 1997, Williams & Wilkins, Baltimore, Maryland, pp.699-700.
Figs 1 & 2: Small intestine: Acute necrohemorrhagic enteritis with moderate submucosal edema. H&E. (objective =16).
Fig 2: Small intestine. Acute necrohemorrhagic enteritis with moderate submucosal edema. H&E. (objective =16).