These rats were the offspring (F1) of a group of rats which were fed a compound from day 0 of pregnancy until weaning at 23 days of age.
Compound X (100 mg/kg PO) was given 5 days prior to necropsy.
These tissues were part of a study examining the pulmonary toxicity and carcinogenicity of an inhaled substance in F344 rats.
Acrylamide was used to induce lesions for positive-control neuropathology in accordance with the EPA’s Tier 2 regulations on toxicology of engine emissions from testing fuels and fuel additives (40 CFR, Part 79.66(e)(3)).
Rats were administered Compound X or Compound Y daily by the oral gavage route for 10 days. Animals sacrificed on Day 5 and Day 10.