5Z6/4A-37 fed Compound X at 100 ppm for 4 weeks beginning at 2 months of age.
Rat in high-dose group on 2-year inhalation carcinogenicity study.
Retina in the rat and dog given Compound X once daily by gavage.
Acrylamide was used to induce lesions for positive-control neuropathology in accordance with the EPA’s Tier 2 regulations on toxicology of engine emissions from testing fuels and fuel additives (40 CFR, Part 79.66(e)(3)).
Rats were administered Compound X or Compound Y daily by the oral gavage route for 10 days. Animals sacrificed on Day 5 and Day 10.