Calves developed clinical signs of weakness, ataxia, depression, dehydration, diarrhea, and loss of appetite; Four died. A white powdery substance was found nearby.
Groups of female rats, 10-11 weeks old, were exposed to a toxic vapor 6 hrs/day, 5 days/week for 6 weeks. The rats were then observed for 18 months after the end of exposure.
The photomicrographs are from rats with chronic, lifetime, whole body aerosol exposure to a test compound for 6 hours/day, 5 days/week, for 2 years.
The rats were part of a study to assess toxic effects and carcinogenesis mechanisms of inhaled nickel subsulfide (Ni3S2).
Treated with a test compound administered subcutaneously daily for 46 days.