Male Fischer 344 rats, from 19 to 32 weeks old

SIGNALMENT: (age, breed, sex, species, and scientific name) 

Male Fischer 344 rats, from 19 to 32 weeks old.

HISTORY:
The rats were part of a study to assess toxic effects and carcinogenesis mechanisms of an inhaled test compound. The rats were exposed, whole-body, to aerosols of this test compound for 6 hours/day, 5 days/week, and 13 weeks. After the exposure period, one group of animals was held to recover for an additional 13 weeks prior to necropsy.

What's Your Diagnosis? Provide your possible etiologies in the comments section. 
Answers will be provided in March.

 

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4x, H&E. Low magnification photomicrograph of lung from a control rat exposed to filtered air for 13 weeks.


r084b.jpg

4x, H&E. Low magnification photomicrograph of lung from a rat exposed to test compound.


 
r084c.jpg

10x, H&E. Lung from rat exposed to test compound. 


 
r084d.jpg

20x, H&E. Lung from rat exposed to test compound. 
 

r084e.jpg

10x, H&E. Lung from rat exposed to test compound.


 
r084f.jpg

20x, H&E. Lung from rat exposed to test compound.


 

 

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