SIGNALMENT: (age, breed, sex, species, and scientific name)
TREATMENT PROTOCOL: (including test compound identification, dose, and class of molecule)
LABORATORY RESULTS: (clinical pathology, microbiology, etc…)
MORPHOLOGIC DIAGNOSI(E)S AND ETIOLOGY:
CONTRIBUTOR'S COMMENTS: (Proposed pathogenesis of the lesion(s), important considerations and diagnostic features, discussion of controversial issues).
PCBs have been well documented to be carcinogenic in laboratory animals and may be carcinogenic in humans(1,2) In these liver slides a range of lesions is present including : (1) focal hepatocellular atrophy with loss of hepatocytes and fibrosis (2) focal fibroacinar formation (3)hepatocellular acinar formation (4) hepatocellular adenocarcinoma formation. The ability of hepatocytes to transform into acinar structures was a striking feature.
REFERENCES: (Please submit a photocopy of each reference.)
1 U.S. Environmental Protection Agency (Sept 1996) PCBs : Cancer Dose-Response Assessment and Application to Environmental Mixtures Report No. EPA/600/P - 96 /001F
2 ATSDR (Agency for Toxic Substances and Disease Registry) (Nov 2000) Polychlorinated Biphenyls (Update)
Treated vs Control, Objective of the microscope (2x, 4x, 10x, 20x, 40x, 100x) or the magnification of Electron Micrographs, Type of stain used (H&E, PAS, Trichrome, Osmium, etc.), and Descriptive legend that explains and describes the features in that image. If the contributor wishes to include labels on the images, a separate set of unlabeled images should also be submitted so that RTPA members can examine the case as an unknown first.
Image 1 (6703) 70 day male 40 obj H&E
Image 2 (2005) 70 day female 40 obj H&E
Image 3 (2503) 35 day male 20 obj H&E
Image 4 (5507) 35 day female 20 obj H&E
Image 5 (427) 35 day female 10 obj H&E
Image 6 (427) 35 day female 40 obj H&E
Image 7 (427) 35 day female 5 obj Masson Trichrome stain
70 day male 40x H&E
70 day female 40x H&E