Male and female Charles River CD VAF rats, Charles River Canada, St‑Constant, Quebec. Age at initiation of dosing was 6 to 7 weeks.
Thirty animals per sex per group were given vehicle or an experimental drug. Duration of treatment was 4 weeks.
Measurable decreases in red cell parameters (RBC, HGB, HCT) occurred in males and females. Slight decreases in reticulocytes were evident at week 2 and 4. The magnitude of changes in RBC parameters and reticulocytes was not considered toxicologically important.
Decreases in cholesterol, HDL, LDL and TRIGLYCERIDES were present.
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