Blog Viewer

Four year old (peripubertal) male cynomolgus macaque (Macaca fascicularis), of Indonesian origin

By Tierre Miller posted 06-10-2020 13:37

  

SIGNALMENT:
Case 98150. Four year old (peripubertal) male cynomolgus macaque (Macaca fascicularis), of Indonesian origin.

TREATMENT PROTOCOL:
Animals dosed with a fusion protein at 10 micrograms/kg/day x 5 days.

GROSS PATHOLOGY:
Heart: There were 8 small (1-3 mm) focal hemorrhages on the epicardial surface of the ventricles.

The lungs were diffusely heavy (27.5 and 31.38 grams, approximately 5 times normal weight), dark red, and wet. White foam exuded from the trachea and major bronchi.

LABORATORY RESULTS:
On the day before euthanasia CBC results included:

  • PCV 37%;
  • WBC 2.1 x 103/mm3
    • 1% segs
    • 97% lymphs
    • 2% monos
    • 0% eos
    • 0% basos
    • platelets 69,000/mm3.


What's Your Diagnosis? Provide your possible etiologies in the comment section. 

 

r118a.jpg

2X. H&E stain.  SFemoral bone marrow.  

r118b.jpg

10X. H&E stain.  Femoral bone marrow.  

r118c.jpg

20X. H&E stain.  Femoral bone marrow.

r118d.jpg

40X. H&E stain. Femoral bone marrow.  

0 comments
27 views

Permalink